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Do alterations of endogenous angiotensin II levels regulate erythropoietin production in humans? by S. Freudenthaler; P. Benöhr; A. Grenz; T. Selzer; T. Schmidt; K. Mörike; H. Osswald; C. H. Gleiter is a Medicine article available to read on EtoBox.

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**Aims** Recent evidence suggests a potential role of angiotensin II in the physiological regulation of erythropoietin (Epo) production. While the administration of exogenous angiotensin II (AII) has been used so far to study its effects, the role of endogenous AII has remained unclear. **Methods** To alter endogenous AII in humans experimentally we used furosemide bolus injection as a short‐term (study 1) and dietary salt as a long‐term modulator (study 2). In an open crossover design, 12 healthy male volunteers received furosemide (F) 0.5 mg kg^−1^ intravenously or placebo (P) in random order (study 1). With the same design, 12 volunteers received high‐salt (HS), normal‐salt (NS) and low‐salt (LS) diet (study 2). Plasma renin activity (PRA) was analysed along with AII. Inulin and paraaminohippurate (PAH) clearances were used to indicate glomerular filtration rate (GFR) and renal plasma flow (RPF), respectively. **Results** While F stimulated AII and PRA and decreased GFR and RPF significantly, no concomitant alteration of Epo was observed [AUCEpo: placebo 5709 ± 243 (% of baseline × h), furosemide: 5833 ± 255 (% of baseline × h); 95% confidence interval (CI) − 608.4, 856.0; __P__

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Author

S. Freudenthaler; P. Benöhr; A. Grenz; T. Selzer; T. Schmidt; K. Mörike; H. Osswald; C. H. Gleiter

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

2003

Language

EN

Field

Medicine (Health Sciences)