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Wong Et Al., 2021, Cell 184 Homeostasis 1-S2.0-S0092867421006589-Main by ador557 is a document available to read on EtoBox.

The study identifies a paracrine feedback mechanism where self-activated T cells produce IL-2, enhancing the function and density of regulatory T cells (Tregs) to prune self-reactive T cells, thereby maintaining immune homeostasis. This feedback circuit constrains activated T cell signaling, leading to transient clonal expansion followed by rapid death of self-activated T cells. The findings highlight the importance of Treg micro-domains in preventing autoimmunity and ensuring a balance between immune respo

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ador557

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EN