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Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI2)-mediated reductive alkylation reaction by Yoshikazu Sasaki; Akira Shigenaga; Nobutaka Fujii; Akira Otaka is a Chemistry article available to read on EtoBox.

What is Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI2)-mediated reductive alkylation reaction about?

The amide bond between an amino acid and proline can take the trans-or cis-conformation. The conformation influences both the structure and function of peptides and proteins. Therefore, constrained mimetic, which corresponds to Pro-dipeptides whose amide bond is replaced with an (E)-or (Z)-alkene, is a useful bioprobe for elucidating the structure-function relationship of peptides and proteins. Herein, we report the synthesis of cis-(Z)-alkene-containing Pro-dipeptide mimetics via a samarium(II) diiodide (SmI 2 )-mediated reductive alkylation reaction.

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Author

Yoshikazu Sasaki; Akira Shigenaga; Nobutaka Fujii; Akira Otaka

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2007

Language

EN

Field

Chemistry (Physical Sciences)