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This study investigates the genomic variability of the HCT116 colorectal cancer cell line using Oxford Nanopore sequencing, identifying a total of 22,666 large genomic rearrangements (LGRs) and copy number variants (CNVs). The research highlights significant differences in LGRs between laboratory and SRA NCBI samples, suggesting unique mechanisms of genomic instability. The findings provide a comprehensive understanding of the genetic landscape of HCT116, which is crucial for future drug development and mol

Author

chetoparra5

Language

EN