Can I read Estrogen and Progesterone Modulate Monocyte Cell Cycle Progression and Apoptosis on EtoBox?

Estrogen and Progesterone Modulate Monocyte Cell Cycle Progression and Apoptosis by T. Thongngarm; J. K. Jenkins; K. Ndebele; R. W. McMurray is a Medicine article available to read on EtoBox.

What is Estrogen and Progesterone Modulate Monocyte Cell Cycle Progression and Apoptosis about?

**PROBLEM:** Pregnancy is characterized by dramatic immunologic changes most commonly characterized as suppression of cell‐mediated immunity. Mechanisms of this immunosuppression are obscure but may be caused by increases in pregnancy‐associated sex steroids such as 17‐β‐estradiol or progesterone. **METHOD OF STUDY:** Using five myelomonocytic cell lines in various stages of differentiation, the effects of 17‐β‐estradiol and progesterone on cell cycling, apoptosis, and bcl‐2 expression in randomly cycling cells before and after lipopolysaccharide (LPS) activation were examined. **RESULTS:** Lipopolysaccharide alone inhibited cell cycle progression in THP‐1 monocyte‐like cells and U‐937 histiocyte‐like cells. Estrogen alone produced cell cycle arrest in all myelomonocytic cells except HL‐60 pro‐myelocyte‐like cells. Progesterone had effects predominantly on pro‐myelocytic‐like HL‐60 cells, inducing apoptosis. Estrogen and progesterone both decreased levels of bcl‐2 in KG‐1α, HL‐60, and THP‐1 cells. LPS partially antagonized both estrogen‐induced THP‐1 apoptosis and its suppression of bcl‐2 protein. **CONCLUSIONS:** Sex steroid‐induced effects on cell cycle transition and apoptosis a

Who reads Estrogen and Progesterone Modulate Monocyte Cell Cycle Progression and Apoptosis?

Author

T. Thongngarm; J. K. Jenkins; K. Ndebele; R. W. McMurray

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 8755-8920)

Published

2003

Language

EN

Field

Medicine (Health Sciences)