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Corticofugal Influences on Thalamic Neurons During Nociceptive Transmission in Awake Rats by Jin‐Yan Wang; Jing‐Yu Chang; Donald J. Woodward; Luiz A. Baccalá; Ji‐Sheng Han; Fei Luo is a Neuroscience article available to read on EtoBox.

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## Abstract Pain is a multidimensional phenomenon and processed in a neural network. The supraspinal, brain mechanisms are increasingly recognized in playing a major role in the representation and modulation of pain. The aim of the current study is to investigate the functional interactions between cortex and thalamus during nociceptive processing, by observing the pain‐related information flow and neuronal correlations within thalamo‐cortical pathways. Pain‐evoked, single‐neuron activity was recorded in awake Sprague‐Dawley rats with a Magnet system. Eight‐wire microarrays were implanted into four different brain regions, i.e., the primary somatosensory (SI) and anterior cingulate cortex (ACC), as well as ventral posterior (VP) and medial dorsal thalamus (MD). Noxious radiant heat was delivered to the rat hind paws on the side contralateral to the recording regions. A large number of responsive neurons were recorded in the four brain areas. Directed coherence analysis revealed that the amount of information flow was significantly increased from SI cortex to VP thalamus following noxious stimuli, suggesting that SI cortex has descending influence on thalamic neurons during pain pro

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Author

Jin‐Yan Wang; Jing‐Yu Chang; Donald J. Woodward; Luiz A. Baccalá; Ji‐Sheng Han; Fei Luo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

2007

Language

EN

Field

Neuroscience (Life Sciences)