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IT3F: A web-based tool for functional analysis of transcription factors in plants by Paul C. Bailey; Jo Dicks; Trevor L. Wang; Cathie Martin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is IT3F: A web-based tool for functional analysis of transcription factors in plants about?

A web-based tool, the Interspecies Transcription Factor Function Finder (IT3F), has been developed to display both evolutionary gene relationships and expression data for plant transcription factors, focussing primarily on the R2R3MYB gene subfamily for proof of concept. The graphical display of information allows users to make direct comparisons between structurally related genes and to identify those genes that are potentially orthologous, thereby assisting with their understanding of gene function. A key feature of the website is the provision of an interrogative phylogenetic tree that allows submission of new sequences corresponding to a transcription factor family or subfamily and maps their relative positions to the products of other genes on an 'existing' tree containing proteins encoded by Arabidopsis and rice genes, along with key proteins encoded by genes from other species that have been characterised functionally. In addition, a feature to select clusters of related sequences has been developed so that more detailed phylogenetic analysis can be performed to highlight potential orthologous and paralogous genes within related clusters. Arabidopsis genes that reside on dup

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Author

Paul C. Bailey; Jo Dicks; Trevor L. Wang; Cathie Martin

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0031-9422)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)