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European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and therapy of glucocorticoid-induced adrenal insufficiency by Felix Beuschlein & Tobias Else & Irina Bancos & Stefanie Hahner & Oksana Hamidi & Leonie van Hulsteijn & Eystein S. Husebye & Niki Karavitaki & Alessandro Prete & Anand Vaidya & Christine Yedinak & Olaf M. Dekkers is a book available to read on EtoBox.

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DOI: 10.1093/ejendo/lvae029; European Journal of Endocrinology, 190, 5, 2024-05-08.; Abstract: Glucocorticoids are widely prescribed as anti-inflammatory and immunosuppressive agents. This results in at least 1% of the population using chronic glucocorticoid therapy, being at risk for glucocorticoid-induced adrenal insufficiency. This risk is dependent on the dose, duration and potency of the glucocorticoid, route of administration, and individual susceptibility. Once glucocorticoid-induced adrenal insufficiency develops or is suspected, it necessitates careful education and management of affected patients. Tapering glucocorticoids can be challenging when symptoms of glucocorticoid withdrawal develop, which overlap with those of adrenal insufficiency. In general, tapering of glucocorticoids can be more rapidly within a supraphysiological range, followed by a slower taper when on physiological glucocorticoid dosing. The degree and persistence of HPA axis suppression after cessation of glucocorticoid therapy are dependent on overall exposure and recovery of adrenal function varies greatly amongst individuals. This first European Society of Endocrinology/Endocrine Society joint clinic

Author

Felix Beuschlein & Tobias Else & Irina Bancos & Stefanie Hahner & Oksana Hamidi & Leonie van Hulsteijn & Eystein S. Husebye & Niki Karavitaki & Alessandro Prete & Anand Vaidya & Christine Yedinak & Olaf M. Dekkers

Publisher

Oxford University Press

Published

2024

Language

EN