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How much total ovarian tissue can be removed without compromising ovarian function? An animal study by Jiaojiao Cheng; Xiangyan Ruan; Qi Zhou; Yanglu Li; Juan Du; Fengyu Jin; Husheng Wang; Muqing Gu; Alfred Otto Mueck is a Medicine article available to read on EtoBox.
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## Objective: Removal of ovarian tissue is a new option for fertility preservation for certain cancer patients in china. the aim was to investigate the impact of stepwise removed tissue on hormone levels and follicles in rats. ## Methods: Six to ten-week old rats were divided into six groups (% total ovarian tissue): 1 = control (100%), 2 (75%), 3 (50%), 4 (25%), 5 (12.5%), 6 (0%, bilateral ovariectomy). blood test was carried out fortnightly to assess estradiol (e2), progesterone (p), follicle-stimulating hormone (fsh), anti-müllerian hormone (amh), and inhibin b (inhb). ovaries are obtained from surgical resections and from rats sacrificed after 12 weeks. ## Results: During 12 weeks, groups 4, 5, and 6 had higher fsh and lower amh and inhb values compared to control (< .05), but in group 4 e2 and p was not significantly different from control ( .05). all ovarian function parameters stopped in groups 5 and 6. follicle morphology was not significantly different between baseline and 12 weeks after surgery in groups 1-5. ## Conclusions: For the first time, we demonstrated that even up to 75% of total ovarian tissue can be removed without impact on e2 and p production in rats, which,
Who reads How much total ovarian tissue can be removed without compromising ovarian function? An animal study?
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- Author
- Jiaojiao Cheng; Xiangyan Ruan; Qi Zhou; Yanglu Li; Juan Du; Fengyu Jin; Husheng Wang; Muqing Gu; Alfred Otto Mueck
- Publisher
- Informa plc; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 0951-3590)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)