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Computational modelling of cancer nanomedicine: Integrating hyperthermia treatment into a multiphase porous-media tumour model by Wirthl, Barbara; Decuzzi, Paolo; Schrefler, Bernhard A.; Wall, Wolfgang A. is a scholarly article available to read on EtoBox.

What is Computational modelling of cancer nanomedicine: Integrating hyperthermia treatment into a multiphase porous-media tumour model about?

Heat-based cancer treatment, so-called hyperthermia, can be used to destroy tumour cells directly or to make them more susceptible to chemotherapy or radiation therapy. To apply heat locally, iron oxide nanoparticles are injected into the bloodstream and accumulate at the tumour site, where they generate heat when exposed to an alternating magnetic field. However, the temperature must be precisely controlled to achieve therapeutic benefits while avoiding damage to healthy tissue. We therefore present a computational model for nanoparticle-mediated hyperthermia treatment fully integrated into a multiphase porous-media model of the tumour and its microenvironment. We study how the temperature depends on the amount of nanoparticles accumulated in the tumour area and the specific absorption rate of the nanoparticles. Our results show that host tissue surrounding the tumour is also exposed to considerable doses of heat due to the high thermal conductivity of the tissue, which may cause pain or even unnecessary irreversible damage. Further, we include a lumped and a discrete model for the cooling effect of blood perfusion. Using a discrete model of a realistic microvasculature reveals th

Author

Wirthl, Barbara; Decuzzi, Paolo; Schrefler, Bernhard A.; Wall, Wolfgang A.

Published

2025

Language

EN