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HDAC inhibitor MS‐275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis by Zhi‐Yuan Zhang; Hermann J. Schluesener is a Medicine article available to read on EtoBox.

What is HDAC inhibitor MS‐275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis about?

## Abstract ## BACKGROUND Experimental autoimmune prostatitis (EAP) is an autoimmune inflammatory disease of male sex accessory glands and is characterized by a cellular and humoral prostate‐specific autoimmune response. EAP shares important clinical and immunological features with human chronic prostatitis and chronic pelvic pain syndrome. MS‐275, a potent histone deacetylase inhibitor, has promising anti‐inflammatory activities and might be a new agent in the therapy of prostate inflammation. ## METHODS EAP rats were treated with MS‐275 (5 mg/kg, i.p.) once daily. Using immunohistochemistry and PCR assay, we determined immune cellular responses and infiltration into the prostate glands, and changes of mRNA levels of representative inflammatory molecules in prostate tissue. Changes in Foxp3^+^CD4^+^ cell populations of lymph nodes and peripheral blood were analyzed by flow cytometry. Additionally, direct anti‐inflammatory effects of MS‐275 were investigated in vitro with a macrophage cell line. ## RESULTS MS‐275 treatment significantly reduced the local accumulation of immune cells and mRNA levels of representative pro‐inflammatory molecules in prostate tissue. Furthermore, MS‐275

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Author

Zhi‐Yuan Zhang; Hermann J. Schluesener

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2011

Language

EN

Field

Medicine (Health Sciences)