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This document reviews the genetics of neurodegenerative diseases and discusses how genetic findings are providing insights into disease pathogenesis. It divides neurodegenerative diseases into four classes based on shared pathogenic mechanisms: tauopathies, synucleinopathies, ubiquitin inclusion diseases, and polyglutamine diseases. The genetics of tauopathies such as FTDP-17T and diseases like progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are discussed in detail. Identifying dise

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