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Elevated Serum Trimethylamine N-Oxide Levels Are Associated with Mortality in Male Patients on Peritoneal Dialysis by Dongying Fu; Jiani Shen; Wei Li; Yating Wang; Zhong Zhong; Hongjian Ye; Naya Huang; Li Fan; Xiao Yang; Xuqing Yu; Yi Zhou; Haiping Mao is a Medicine article available to read on EtoBox.
What is Elevated Serum Trimethylamine N-Oxide Levels Are Associated with Mortality in Male Patients on Peritoneal Dialysis about?
**__Background:__** Elevated levels of serum trimethylamine N-oxide (TMAO) have been previously linked to adverse cardiovascular (CV) and all-cause mortality in hemodialysis patients. However, the clinical significance of serum TMAO levels in patients treated with peritoneal dialysis (PD) is unclear. **__Methods:__** A total of 1,032 PD patients with stored serum samples at baseline were enrolled in this prospective study. Serum concentrations of TMAO were quantified by ultra-performance liquid chromatography-tandem mass spectrometry. Cox proportional hazards and competing-risk regression models were performed to examine the association of TMAO levels with all-cause and CV mortality. **__Results:__** The median level of serum TMAO in our study population was 34.5 (interquartile range (IQR), 19.8–61.0) μM. During a median follow-up of 63.7 months (IQR, 43.9–87.2), 245 (24%) patients died, with 129 (53%) deaths resulting from CV disease. In the entire cohort, we observed an association between elevated serum TMAO levels and all-cause mortality (adjusted subdistributional hazard ratio [SHR], 1.22; 95% confidence interval [95% CI], 1.01–1.48; __p__ = 0.039) but not CV mortality. Furthe
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- Author
- Dongying Fu; Jiani Shen; Wei Li; Yating Wang; Zhong Zhong; Hongjian Ye; Naya Huang; Li Fan; Xiao Yang; Xuqing Yu; Yi Zhou; Haiping Mao
- Publisher
- S. Karger AG
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)