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Vaccines Targeting the Neovasculature of Tumors by Agata Matejuk; Qixin Leng; Szu-Ting Chou; Archibald J Mixson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Vaccines Targeting the Neovasculature of Tumors about?

Angiogenesis has a critical role in physiologic and disease processes. For the growth of tumors, angiogenesis must occur to carry sufficient nutrients to the tumor. In addition to growth, development of new blood vessels is necessary for invasion and metastases of the tumor. A number of strategies have been developed to inhibit tumor angiogenesis and further understanding of the interplay between tumors and angiogenesis should allow new approaches and advances in angiogenic therapy. One such promising angiogenic approach is to target and inhibit angiogenesis with vaccines. This review will discuss recent advances and future prospects in vaccines targeting aberrant angiogenesis of tumors. The strategies utilized by investigators have included whole endothelial cell vaccines as well as vaccines with defined targets on endothelial cells and pericytes of the developing tumor endothelium. To date, several promising anti-angiogenic vaccine strategies have demonstrated marked inhibition of tumor growth in pre-clinical trials with some showing no observed interference with physiologic angiogenic processes such as wound healing and fertility.

Who reads Vaccines Targeting the Neovasculature of Tumors?

Author

Agata Matejuk; Qixin Leng; Szu-Ting Chou; Archibald J Mixson

Publisher

BioMed Central; Publiverse Online S.R.L; London: Biomed Central, 2011-2017.; Bucureşti: Publiverse Online, 2017-; Springer Nature (ISSN 2045-824X)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)