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Proteome Analysis of Differential Protein Expression in Allergen-induced Asthmatic Mice Lung After Dexamethasone Treatment by Gu Seob Roh; YoungHyun Shin; Seong-Won Seo; Bo Ra Yoon; SinKoo Yeo; Sung Jin Park; Jin Won Cho; KyuBum Kwack is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Proteome Analysis of Differential Protein Expression in Allergen-induced Asthmatic Mice Lung After Dexamethasone Treatment about?
## Abstract Asthma has become substantially more prevalent in recent decades and is one of the foremost contributors to morbidity and mortality in industrialized countries. Corticosteroids are among the most effective medications for the treatment of asthma, but some patients do not respond well to corticosteroid treatment. In this study, we characterized the responses to an allergen and identified potential molecular targets of dexamethasone (Dex) treatment in acute asthma. Female BALB/c mice sensitized to ovalbumin (OVA) were challenged with aerosolized OVA for 1 week. During the challenge period, mice were treated daily with Dex by intraperitoneal injection. Phosphate‐buffered saline treated and non‐challenged mice served as control. Histological evaluation of OVA‐induced mice revealed airway inflammation and goblet cell hyperplasia. In addition, interleukin 4 levels and interferon‐γ levels were increased and decreased, respectively. These changes were moderated by Dex treatment. Protein expression profiles were compared in each experimental group by two‐dimensional gel electrophoresis and identified using matrix‐assisted laser desorption/ionization‐time of flight/time of flight
Who reads Proteome Analysis of Differential Protein Expression in Allergen-induced Asthmatic Mice Lung After Dexamethasone Treatment?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Gu Seob Roh; YoungHyun Shin; Seong-Won Seo; Bo Ra Yoon; SinKoo Yeo; Sung Jin Park; Jin Won Cho; KyuBum Kwack
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)