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Relationship Between Catalase Haplotype and Arterial Aging by Valérie Nivet-Antoine; Carlos Labat; Said El Shamieh; Xavier Dulcire; Charles-Henry Cottart; Jean-Louis Beaudeux; Faiez Zannad; Sophie Visvikis-Siest; Athanase Benetos is a Medicine article available to read on EtoBox.

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## Background: Although many conventional factors have been associated with the development of arterial aging, cardiovascular diseases remain the first cause of death in old age. therefore, identification of new risk factors may prove promising for monitoring this serious health problem. oxidative stress and particularly catalase (cat), an antioxidant enzyme, play an important role in endothelial cell pathophysiology, in shear stress response and ultimately in arterial aging. ## Objective: Examine the relationships between cat haplotypes and phenotypes of arterial aging (mean internal diameter, mean intima-media thickness of the common carotid arteries (cca), presence of atheromatous plaques) in two french cohorts. ## Methods and results: 564 middle-aged french individuals (mean age 53 ± 12 years) from two cohorts (era and stanislas cohorts) were included in the study. blood pressure, cca intima-media thickness, cca internal diameter and number of atheromatous plaques were measured. catalase rs769214 snp genotyping was performed. we identified a cat haplotype that influences arterial aging. individuals carrying the cat2 haplotype had a higher mean internal diameter of cca with agin

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Author

Valérie Nivet-Antoine; Carlos Labat; Said El Shamieh; Xavier Dulcire; Charles-Henry Cottart; Jean-Louis Beaudeux; Faiez Zannad; Sophie Visvikis-Siest; Athanase Benetos

Publisher

Elsevier BV

Published

2013

Language

EN

Field

Medicine (Health Sciences)