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Coordinated Control of Neuronal Differentiation and Wiring by Sustained Transcription Factors by Mehmet Neset Özel; Claudia Skok Gibbs; Isabel Holguera; Mennah Soliman; Richard Bonneau; Claude Desplan is a Medicine article available to read on EtoBox.

What is Coordinated Control of Neuronal Differentiation and Wiring by Sustained Transcription Factors about?

The large diversity of cell types in nervous systems presents a challenge in identifying the genetic mechanisms that encode it. Here, we report that nearly 200 distinct neurons in the Drosophila visual system can each be defined by unique combinations of on average 10 continuously expressed transcription factors. We show that targeted modifications of this terminal selector code induce predictable conversions of neuronal fates that appear morphologically and transcriptionally complete. Cis-regulatory analysis of open chromatin links one of these genes to an upstream patterning factor that specifies neuronal fates in stem cells. Experimentally validated network models describe the synergistic regulation of downstream effectors by terminal selectors and ecdysone signaling during brain wiring. Our results provide a generalizable framework of how specific fates are implemented in postmitotic neurons.

Who reads Coordinated Control of Neuronal Differentiation and Wiring by Sustained Transcription Factors?

Author

Mehmet Neset Özel; Claudia Skok Gibbs; Isabel Holguera; Mennah Soliman; Richard Bonneau; Claude Desplan

Publisher

American Association for the Advancement of Science (AAAS)

Published

2022

Language

EN

Field

Medicine (Social Sciences)