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MR assessment of changes of tumor in response to hyperbaric oxygen treatment by Ken‐ichiro Matsumoto; Marcelino Bernardo; Sankaran Subramanian; Peter Choyke; James B. Mitchell; Murali C. Krishna; Martin J. Lizak is a Medicine article available to read on EtoBox.

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## Abstract Enhancement of image intensity, using the __T__~1~‐weighted spoiled gradient‐echo (SPGR) sequence, was measured in SCC tumor implanted in the flank of C3H mice while they were subjected to several types of oxygenation challenges inside a hyperbaric chamber designed and constructed to fit in an MRI resonator. The central portions of the tumor gave a positive enhancement, while the periphery showed signal reduction during both normobaric (NBO) and hyperbaric (HBO) oxygen challenges. In the contralateral normal leg, nearly 70% of the region showed a decrease in intensity, and the rest showed a positive enhancement. The positive signal enhancement was markedly greater under HBO compared to NBO. Calculated __R__~1~, __R__~2~, and __M__~0~ maps from multivariate fitting of images acquired by a multislice multiecho (MSME) sequence with variable TR before, during, and after HBO treatment confirm that the source of SPGR signal enhancement in the tumor is associated with shortening of __T__~1~. Magn Reson Med, 2006. Published 2006 Wiley‐Liss, Inc.

Who reads MR assessment of changes of tumor in response to hyperbaric oxygen treatment?

Author

Ken‐ichiro Matsumoto; Marcelino Bernardo; Sankaran Subramanian; Peter Choyke; James B. Mitchell; Murali C. Krishna; Martin J. Lizak

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2006

Language

EN

Field

Medicine (Health Sciences)