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This randomized clinical trial compared the efficacy of pyrimethamine + sulfadiazine (PS) vs spiramycin (S) in reducing placental transmission of toxoplasmosis following maternal infection. 143 women were randomized to receive either PS or S after seroconversion. Amniocentesis showed transmission rates were lower with PS (10.4%) vs S (20.3%), and no fetal abnormalities were found with PS vs 6 cases with S. While PS appeared more effective, the difference was not statistically significant, possibly due to in

Author

sarah disa

Language

EN