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I-131 metaiodobenzylguanidine: Diagnostic use in neuroblastoma patients in relapse by Dr. Sydney Heyman; Audrey E. Evans; Giulio J. D'Angio is a Medicine article available to read on EtoBox.

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Metaiodobenzylguanidine (MIBG) has been used for the detection and treatment of neuroectodermal tumors, including neuroblastoma. We report our experience with I3'l- MIBG used diagnostically in neuroblastoma patients with relapse. Thirtyeight studies were performed in 26 patients. There were 24 children (range 3 months-I4 years) and two adults. While the study was found to be both sensitive and specific for the presence of dis-ease, there are instances of discordance. Falsenegative studies were found with a markedly anaplastic tumor and with two mature ganglioneuromas. A bone lesion was negative with 1311-MIBC, but positive on bone scan. A biopsy confirmed the presence of neuroblastoma. Caution should be exercised when scanning pretreated patients, and perhaps with newly diagnosed patients as well.

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Author

Dr. Sydney Heyman; Audrey E. Evans; Giulio J. D'Angio

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)

Published

1988

Language

EN

Field

Medicine (Health Sciences)