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In vivo validation of tissue segmentation based on a 3D feature map using both a hamster brain tumor model and stereotactically guided biopsy of brain tumors in man by Simon Vinitski; Carlos Gonzalez; David Andrews; Robert Knobler; Mark Curtis; Feroze Mohamed; Jennifer Gordon; Kamel Khalili is a Medicine article available to read on EtoBox.
What is In vivo validation of tissue segmentation based on a 3D feature map using both a hamster brain tumor model and stereotactically guided biopsy of brain tumors in man about?
## Abstract The purpose of this study was to validate our MR tissue segmentation technique using a hamster brain tumor model and malignant brain tumors in man. We used a multispectral tissue segmentation analysis. Three sets of MRI data were included: proton density, T2‐weighted fast spin echo, and T1‐weighted spin echo, as inputs. Three image preprocessing steps included correcting image nonuniformity, application of an anisotropic diffusion type filter, and data point selection by a qualified observer. We used the k‐Nearest Neighbor segmentation algorithm, which does not require prior knowledge of the sample distribution. This choice allowed us to optimize the different tissue clusters present in three‐dimensional (3D) feature space. In vivo validation of the technique was performed in hamsters harboring tumors induced with JC virus‐transformed HJC‐15 cells, as compared to three control animals. Human brain tumors obtained by stereotactically guided biopsy in six patients were also included in the study. Finally, brain tumors were removed from two patients who underwent conventional craniotomy using segmentation‐derived images as a guide. In the hamsters, 10 tissues were correctl
Who reads In vivo validation of tissue segmentation based on a 3D feature map using both a hamster brain tumor model and stereotactically guided biopsy of brain tumors in man?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Simon Vinitski; Carlos Gonzalez; David Andrews; Robert Knobler; Mark Curtis; Feroze Mohamed; Jennifer Gordon; Kamel Khalili
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)