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A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. II. Long‐term in vitro by Young Min Ju; Bazhang Yu; Leigh West; Yvonne Moussy; Francis Moussy is a Engineering article available to read on EtoBox.

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## Abstract We have developed a new 3D porous and biostable collagen scaffold for implantable glucose sensors. The scaffolds were fabricated around the sensors and crosslinked using nordihydroguaiaretic acid (NDGA) or glutaraldehyde (GA) to enhance physical and biological stability. The effect of the scaffolds on sensor function and biocompatibility was examined during long‐term (≥28 days) __in vitro__ and __in vivo__ experiments and compared with control bare sensors. To evaluate the effect of the sensor length on micromotion and sensor function, we also fabricated short and long sensors. 3D porous scaffold application around glucose sensors did not significantly affect the long‐term __in vitro__ sensitivity of the sensors. The scaffolds, crosslinked by either NDGA or GA, remained stable around the sensors during the 4 week __in vitro__ study. In the long‐term __in vivo__ study, the sensitivity of the short sensors was higher than the sensitivity of long sensors presumably because of less micromotion in the subcutis of the rats. The sensors with NDGA‐crosslinked scaffolds had a higher sensitivity than the sensors with GA‐crosslinked scaffolds. Histological examination showed that

Who reads A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. II. Long‐term in vitro?

Author

Young Min Ju; Bazhang Yu; Leigh West; Yvonne Moussy; Francis Moussy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2009

Language

EN

Field

Engineering (Physical Sciences)