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Can I read Immunomodulatory Function of Licensed Human Bone Marrow Mesenchymal Stromal Cell-derived Apoptotic Bodies on EtoBox?
Immunomodulatory Function of Licensed Human Bone Marrow Mesenchymal Stromal Cell-derived Apoptotic Bodies by Jiemin Wang; Ellen Donohoe; Aoife Canning; Seyedmohammad Moosavizadeh; Fiona Buckley; Meadhbh Á. Brennan; Aideen E. Ryan; Thomas Ritter is a Immunology and Microbiology article available to read on EtoBox.
What is Immunomodulatory Function of Licensed Human Bone Marrow Mesenchymal Stromal Cell-derived Apoptotic Bodies about?
Background: Mesenchymal stromal cells (MSCs) show great potential for immunomodulatory and antiinflammatory treatments. Clinical trials have been performed for the treatment of Type 1 diabetes, graftversus-host disease and organ transplantation, which offer a promise of MSCs as an immunomodulatory therapy. Nevertheless, their unstable efficacy and immunogenicity concerns present challenges to clinical translation. It has emerged that the MSC-derived secretome, which includes secreted proteins, exosomes, apoptotic bodies (ABs) and other macromolecules, may have similar therapeutic effects to parent MSCs. Among all of the components of the MSC-derived secretome, most interest thus far has been garnered by exosomes for their therapeutic potential. However, since MSCs were reported to undergo apoptosis after in vivo transplantation and release ABs, we speculated as to whether ABs have immunomodulatory effects. In this study, cytokine licensing was used to enhance the immunomodulatory potency of MSCs and ABs derived from licensed MSCs in vitro were isolated to explore their immunomodulatory effects as an effective non-viable cell therapy. Results: IFN-γ and IFN-γ/TGF-β1 licensing enhanc
Who reads Immunomodulatory Function of Licensed Human Bone Marrow Mesenchymal Stromal Cell-derived Apoptotic Bodies?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Jiemin Wang; Ellen Donohoe; Aoife Canning; Seyedmohammad Moosavizadeh; Fiona Buckley; Meadhbh Á. Brennan; Aideen E. Ryan; Thomas Ritter
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)