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Glutamine Regulates Glutamine Synthetase Expression in Skeletal Muscle Cells in Culture by Bo Feng; Susan K. Shiber; Stephen R. Max is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Metabolite control of glutamine synthetase expression (by glutamine) was studied in L6 skeletal muscle cells. Depletion of glutamine from the culture medium for 24 hours resulted in a 3-4-fold increase in glutamine synthetase activity. This effect was blocked by cycloheximide but not by actinomycin D. Addition of glutamine to L6 cells maintained in glutamine-free medium caused a rapid return of glutamine synthetase activity to the control level. As reported, dexamethasone caused a striking increase in the glutamine synthetase mRNA level. In contrast, neither depletion nor addition of glutamine caused a change in the glutamine synthetase mRNA level. Therefore, regulation of glutamine synthetase by glutamine is exerted at a post-transcriptional level.

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Author

Bo Feng; Susan K. Shiber; Stephen R. Max

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1990

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)