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Human Islet Cell Transplantation – Future Prospects by S. A. White; R. F. L. James; S. M. Swift; R. M. Kimber; M. L. Nicholson is a Medicine article available to read on EtoBox.

What is Human Islet Cell Transplantation – Future Prospects about?

**Summary** **Background** Islet transplantation has the potential to cure diabetes mellitus. Nevertheless despite successful reversal of diabetes in many small animal models, the clinical situation has been far more challenging. The aim of this review is to discuss why insulin‐independence after islet allotransplantation has been so difficult to achieve. **Methods** A literature review was undertaken using Medline from 1975 to July 2000. Results reported to the International Islet Transplant Registry (ITR) up to December 1998 were also analysed. **Results** Up to December 1998, 405 islet allotransplants have been reported the ITR. Of those accurately documented between 1990 and 1998 (__n__ = 267) only 12% have achieved insulin‐independence (greater than 7 days). However with refined peri‐transplant protocols insulin indepedence at 1 year can reach 20%. **Conclusions** There are many factors which can explain the failure of achieving insulin‐independence after islet allotransplantation. These include the use of diabetogenic immunosuppressive agents to abrogate both islet allo‐immunity and auto‐immunity, the critical islet mass to achieve insulin‐independence and the detrimental eff

Who reads Human Islet Cell Transplantation – Future Prospects?

Author

S. A. White; R. F. L. James; S. M. Swift; R. M. Kimber; M. L. Nicholson

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3071)

Published

2001

Language

EN

Field

Medicine (Health Sciences)