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Gpr161 Deletion Impacts Forebrain Development by carmen lau is a document available to read on EtoBox.
The study investigates the effects of Gpr161 deletion on Sonic hedgehog (Shh) signaling in the forebrain, revealing significant developmental abnormalities such as hydrocephalus and altered cortical structure. Increased Shh signaling due to Gpr161 absence leads to radial glial over-proliferation and disrupted neuronal migration, resulting in conditions like polymicrogyria and periventricular nodular heterotopia. The findings highlight the importance of Gpr161 in regulating Shh pathway activity during early
- Author
- carmen lau
- Language
- EN