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Transient Inflammatory Response Induced by Apoptotic Cells Is an Important Mediator of Melanoma Cell Engraftment and Growth by Mariangela Correa; Joel Machado Jr.; Célia R.W. Carneiro; João Bosco Pesquero; Michael Bader; Luiz R. Travassos; Roger Chammas; Miriam G. Jasiulionis is a Medicine article available to read on EtoBox.
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## Abstract Two murine melanoma cell lines, Tm1 and Tm5, were derived from a nontumorigenic lineage of pigmented murine melanocytes, melan‐a. Both Tm1 and Tm5 are invariably tumorigenic in syngeneic mice when inoculated s.c. in doses higher than 10^4^ cells; 10^3^ or fewer cells rarely give rise to tumors. We demonstrate that subtumorigenic inocula of Tm1 or Tm5 cells (10^3^) as well as of a known murine melanoma cell line (B16F10) develop as vigorously growing tumor grafts only when coinoculated with apoptotic, but not necrotic cells. The presence of apoptotic cells correlates with a transient inflammatory infiltrate, composed mainly of neutrophils and macrophages. Kinin B1 receptor–deficient mice, which have impaired transmigration of neutrophils to inflamed tissues, had significant growth inhibition of subtumorigenic doses of melanoma cells coinjected with apoptotic cells. Using the same model, tumor take in athymic mice was similar to that seen in wild‐type mice, suggesting that a T cell–dependent inflammatory response is not necessary to promote the survival and growth of subtumorigenic doses of melanoma cells. Taken together, our results describe how tumor engraftment and gro
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- Author
- Mariangela Correa; Joel Machado Jr.; Célia R.W. Carneiro; João Bosco Pesquero; Michael Bader; Luiz R. Travassos; Roger Chammas; Miriam G. Jasiulionis
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)