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Can I read A Phase II trial of methotrexate, vinblastine, doxorubicin, and cisplatin in the treatment of metastatic carcinoma of the uterine cervix on EtoBox?
A Phase II trial of methotrexate, vinblastine, doxorubicin, and cisplatin in the treatment of metastatic carcinoma of the uterine cervix by Christos A. Papadimitriou; Meletios A. Dimopoulos; Nikolaos Giannakoulis; Kyrillos Sarris; Georgios Vassilakopoulos; Thrasyvoulos Akrivos; Zannis Voulgaris; Georgios Vlahos; Emmanouil Diakomanolis; Stylianos Michalas is a Medicine article available to read on EtoBox.
What is A Phase II trial of methotrexate, vinblastine, doxorubicin, and cisplatin in the treatment of metastatic carcinoma of the uterine cervix about?
## Background: Patients with metastatic carcinoma of the uterine cervix have limited survival. thus, new chemotherapeutic agents and combinations are needed to improve patient outcome. ## Methods: Twenty-seven patients with stage iv primary or recurrent carcinoma of the uterine cervix were assigned to chemotherapy treatment at 4-week intervals with methotrexate, vinblastine, doxorubicin, and cisplatin (mvac). the treatment was comprised of methotrexate, 30 mg/m2 administered intravenously (i.v.) on days 1, 15, and 22; vinblastine, 3 mg/m2 i.v. on days 2, 15, and 22; doxorubicin, 30 mg/m2 i.v. on day 2; and cisplatin, 70 mg/m2 i.v. on day 2. granulocyte-colony stimulating factor (g-csf) was given subcutaneously on days 6-10 at a dose of 5 micrograms/kg. ## Results: After a median of 4 cycles (a maximum of 6 in responders), the authors observed objective responses in 14 patients (52%), including 3 complete responses (11%) and 11 partial responses (41%). median overall survival was 11 months (range, 4-15+ months), and median progression free survival of the responders was 8 months (range, 6-15+ months). toxicity was acceptable and included neutropenia, alopecia, vomiting, and stomatit
Who reads A Phase II trial of methotrexate, vinblastine, doxorubicin, and cisplatin in the treatment of metastatic carcinoma of the uterine cervix?
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- Author
- Christos A. Papadimitriou; Meletios A. Dimopoulos; Nikolaos Giannakoulis; Kyrillos Sarris; Georgios Vassilakopoulos; Thrasyvoulos Akrivos; Zannis Voulgaris; Georgios Vlahos; Emmanouil Diakomanolis; Stylianos Michalas
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)