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Preclinical Therapeutic Response of Residual Metastatic Disease Is Distinct from Its Primary Tumor of Origin by Chi-Ping Day; John Carter; Carrie Bonomi; Melinda Hollingshead; Glenn Merlino is a Medicine article available to read on EtoBox.

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## Abstract Cancer‐related deaths are caused principally by recurrence and metastasis arising from residual disease, whose therapeutic responses has been suggested to be substantially different from primary tumors. However, experimental animal models designed for evaluating the therapeutic responses of residual disease are mostly lacking. To overcome this deficiency, we have developed a preclinical model that recapitulates the progression for advanced nonsmall cell lung cancer (NSCLC). An archived Lewis lung carcinoma mouse tumor, propagated only through serial __in vivo__ transplantation and never adapted to cell culture, was stably labeled using lentivirus‐encoded biomarkers, consistently expressed through an RNA polymerase II promoter. Labeled tumors were inoculated into syngeneic immunocompetent mice to ensure superior tumor–host interactions. Primary tumors were resected on reaching a predetermined size, followed by treatment in a setting akin to postsurgical first‐line adjuvant chemotherapy and routine imaging to monitor the progression of pulmonary metastasis. We discovered that efficacious treatment, instead of reducing disease growth rates, significantly prolonged disease‐

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Author

Chi-Ping Day; John Carter; Carrie Bonomi; Melinda Hollingshead; Glenn Merlino

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2011

Language

EN

Field

Medicine (Health Sciences)