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Nucleotide‐binding and oligomerization domain (NOD)‐like receptors in teleost fish: Current knowledge and future perspectives by Liang Zhang; Zhuying Gao; Li Yu; Bo Zhang; Jing Wang; Jun Zhou is a Immunology and Microbiology article available to read on EtoBox.

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## Abstract Nucleotide‐binding and oligomerization domain (NOD)‐like receptors (NLRs) are a group of intracellular pathogen recognition receptors (PRRs) that play key roles in pathogen recognition and subsequent activation of innate immune signalling pathways. Expressions of several NLR subfamily members, including NOD1, NOD2, NLR‐C3, NLR‐C5 and NLR‐X1 have been reported in many different teleost fish species. These receptors are activated by a variety of ligands, including lipopolysaccharides (LPS), peptidoglycans (PGN) and polyinosinic‐polycytidylic acid [Poly(I:C)]. Synthetic dsRNA and bacterial or viral infections are known to stimulate these receptors both in vitro and in vivo. In this review, we focus on the identification, expression and function of teleost NLRs in response to bacterial or viral pathogens. Additionally, NLR ligand specificity and signalling pathways involved in the recognition of bacterial or viral stimuli are also summarized. This review focuses on current knowledge in this area and provides future perspectives regarding topics in need of additional investigation. Understanding the response of innate immune system to bacterial or viral infections in diverse

Who reads Nucleotide‐binding and oligomerization domain (NOD)‐like receptors in teleost fish: Current knowledge and future perspectives?

Author

Liang Zhang; Zhuying Gao; Li Yu; Bo Zhang; Jing Wang; Jun Zhou

Publisher

Wiley

Published

2018

Language

EN

Field

Immunology and Microbiology (Life Sciences)