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The puzzle of the hepatitis B genotype distribution and evolution in Africa by Christophe M. Olinger is a Medicine article available to read on EtoBox.
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## Abstract The hepatitis B virus (HBV) is currently estimated to chronically infect almost 400 million people worldwide of which 65 millions live on the African continent. Based on the nucleotide distance between complete genomes, the circulating hepatitis B strains have been classified into different genotypes and subtypes most of which present a specific geographic distribution. Numerous phylogenetic studies have determined the genotypes and subtypes of HBV circulating in Africa, and have revealed a surprising picture. The most prevalent genotype found was genotype E, mostly in sub-Saharan Africa followed by genotype A distributed in sub-Saharan Africa but also in the South and East of Africa, and genotype D, which was mostly found in North Africa. While the evolutionary history of genotype A has seen an obvious diversification with the appearance of several subtypes, genotype E did not undergo a similar evolutionary history. In fact, genotype E and A co-circulate in several countries but although genotype A strains show a high diversity from country to country, the diversity among genotype E strains found in the same countries is very low. While this low diversity suggests a re
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- Author
- Christophe M. Olinger
- Publisher
- Walter de Gruyter GmbH
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)