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Selective effects of the PKC inhibitors Ro 31-8220 and CGP 41 251 on PMN locomotion, cell polarity, and pinocytosis by H. U. Keller; V. Niggli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Using two newly synthesized inhibitors, Ro 31-8220 and CGP 41 251, of protein kinase C (PKC), we analysed: (1) how distinct PMN functions (shape changes, locomotion, pinocytosis) are regulated, and (2) the role of protein phosphorylation and PKC in this process. We were able to transform: (1) resting PMNs into locomoting cells using fNLPNTL, (2) locomoting cells into non-locomoting highly pinocytic cells using PMA, and (3) PMA-stimulated cells showing marked pinocytosis into locomoting or into resting cells using Ro 31-8220. It is thus possible to selectively manipulate PMN function (resting state, locomotion, marked pinocytosis), indicating that there are different regulatory pathways. It was not possible to

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Author

H. U. Keller; V. Niggli

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1994

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)