Opening book details…
Can I read Protein Expression of Cancer Testis Antigens Predicts Tumor Recurrence and Treatment Response to Imatinib in Gastrointestinal Stromal Tumors on EtoBox?
Protein Expression of Cancer Testis Antigens Predicts Tumor Recurrence and Treatment Response to Imatinib in Gastrointestinal Stromal Tumors by Daniel Perez; Fabian Hauswirth; Dirk Jäger; Urs Metzger; Eleftherios Pierre Samartzis; Philip Went; Achim Jungbluth is a Medicine article available to read on EtoBox.
What is Protein Expression of Cancer Testis Antigens Predicts Tumor Recurrence and Treatment Response to Imatinib in Gastrointestinal Stromal Tumors about?
## Abstract Cancer testis antigens (CTAs) have been identified in various tumors as immunological tumor targets. In gastrointestinal stromal tumor (GIST), the prediction of malignant potential remains difficult but is crucial in the era of adjuvant imatinib treatment. Here, we analyzed the impact of CTAs on tumor recurrence and its role on the treatment response to imatinib. The expression of the most frequent CTAs MAGE‐A1, MAGE‐A3, MAGE‐A4, MAGE‐C1 and NY‐ESO‐1 was analyzed by immunohistochemistry. The duration between the initial operation and the tumor relapse was defined as recurrence free survival (RFS). All recurrent cases were treated with imatinib. The tumor response to imatinib was graded according to the modified CT response evaluation criteria. Patients with a CTA positive GIST (__n__ = 23, 27%) had a significantly shorter RFS (__p__ = 0.001) compared to negative cases (__n__ = 63, 73%). The median RFS was 25 months in CTA positive patients and was not reached during the study period in CTA negative patients. According to the established staging criteria CTA positive tumors were predominantly high‐risk tumors (__p__ = 0.001). The expression of MAGE‐A3 (__p__ = 0.018) and
Who reads Protein Expression of Cancer Testis Antigens Predicts Tumor Recurrence and Treatment Response to Imatinib in Gastrointestinal Stromal Tumors?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Daniel Perez; Fabian Hauswirth; Dirk Jäger; Urs Metzger; Eleftherios Pierre Samartzis; Philip Went; Achim Jungbluth
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)