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Lipodystrophy for the Diabetologist—What to Look For by Nivedita Patni; Abhimanyu Garg is a Medicine article available to read on EtoBox.
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## Purpose of review: Genetic or acquired lipodystrophies are characterized by selective loss of body fat along with predisposition towards metabolic complications of insulin resistance, such as diabetes mellitus, hypertriglyceridemia, hepatic steatosis, polycystic ovarian syndrome, and acanthosis nigricans. in this review, we discuss the various subtypes and when to suspect and how to diagnose lipodystrophy. ## Recent findings: The four major subtypes are autosomal recessive, congenital generalized lipodystrophy (cgl); acquired generalized lipodystrophy (agl), mostly an autoimmune disorder; autosomal dominant or recessive familial partial lipodystrophy (fpld); and acquired partial lipodystrophy (apl), an autoimmune disorder. diagnosis of lipodystrophy is mainly based upon physical examination findings of loss of body fat and can be supported by body composition analysis by skinfold measurements, dual-energy x-ray absorptiometry, and whole-body magnetic resonance imaging. confirmatory genetic testing is helpful in the proband and at-risk family members with suspected genetic lipodystrophies. the treatment is directed towards the specific comorbidities and metabolic complications, a
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- Author
- Nivedita Patni; Abhimanyu Garg
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)