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The relationship between MMPs and pH in whole saliva of radiated head and neck cancer patients by T. Vuotila; L. Ylikontiola; T. Sorsa; H. Luoto; R. Hanemaaijer; T. Salo; L. Tjäderhane is a Medicine article available to read on EtoBox.

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## Abstract **Background:** Radiation therapy for head and neck tumour patients may lead to decreased salivary flow, oral mucosal lesions and increased caries experience. Salivary matrix metalloproteinases (MMPs) may participate in the pathogenesis of mucosal lesions and dentinal caries. The aims of this study were: (i) to assay the presence, molecular forms and proteolytic activity of MMP‐8 (collagenase‐2) and MMP‐9 (gelatinase B) in the whole saliva of head and neck cancer patients having radiation therapy; (ii) to see whether salivary pH affects the activity of MMP‐8 and MMP‐9; and (iii) to find out the possible connection between MMP‐8 and MMP‐9 with the eruption of oral mucosal lesions during radiation therapy. **Methods:** The whole saliva samples of 39 head and neck cancer patients having radiation therapy were collected before, during and after radiation therapy, and saliva flow rate, pH, buffer capacity, Streptococcus mutans, Lactobacillus and Candida albicans were measured. Any oral mucosal lesions were examined during each visit. The levels of MMP‐8 were measured by immunofluorometric assay (IFMA) and the presence of different MMP‐8 forms was analysed using Western immun

Who reads The relationship between MMPs and pH in whole saliva of radiated head and neck cancer patients?

Author

T. Vuotila; L. Ylikontiola; T. Sorsa; H. Luoto; R. Hanemaaijer; T. Salo; L. Tjäderhane

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0904-2512)

Published

2002

Language

EN

Field

Medicine (Health Sciences)