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Cancer Protection of Soy Resembles Cancer Protection During Pregnancy by Uwe D. Rohr; Anca G. Gocan; Doris Bachg; Adolf E. Schindler is a Medicine article available to read on EtoBox.

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## Abstract It has been established that carrying a pregnancy to full-term at an early age can protect against contracting cancer by up to 50% in later life. The trophoblast theory of cancer states that trophoblast and cancer tissue are very similar. New findings suggest that the loss of fetal cells during pregnancy resemble those cells responsible for causing metastasis in cancer. Fetal cells and spreading cancer cells are highly proliferative. They are similar to stem cells, exhibiting no or low hormone receptor expression, and require a hormone receptor independent mechanism for control. Control of membrane stability during pregnancy is of vital importance for a successful pregnancy and is mediated by androstenediol and 2-methoxyestradiol. 2-Methoxyestradiol has no hormone receptor affinity and elicits strong anticancer effects particularly against cancer stem cells and fetal cells, for which currently no treatment has yet been established. There is a discussion whether pregnancy reduces cancer stem cells in the breast. Soy isoflavones are structurally similar to both hormones, and elicit strong anticancer effects and antiangiogenesis via inhibition of NF-κB, even in hormone rec

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Author

Uwe D. Rohr; Anca G. Gocan; Doris Bachg; Adolf E. Schindler

Publisher

Walter de Gruyter GmbH

Published

2010

Language

EN

Field

Medicine (Health Sciences)