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Can I read Long-term Exposure to Copper Induces Mitochondria-mediated Apoptosis in Mouse Hearts on EtoBox?
Long-term Exposure to Copper Induces Mitochondria-mediated Apoptosis in Mouse Hearts by Ming Pan; Zi-wei Cheng; Chen-guang Huang; Zhu-qing Ye; Li-jun Sun; Hua Chen; Bei-bei Fu; Kai Zhou; Zhi-rui Fang; Zi-jian Wang; Qing-zhong Xiao; Xue-sheng Liu; Feng-qin Zhu; Shan Gao is a Environmental Science article available to read on EtoBox.
What is Long-term Exposure to Copper Induces Mitochondria-mediated Apoptosis in Mouse Hearts about?
Copper is a trace element necessary for the normal functioning of organisms, but excessive copper contents may be toxic to the heart. The goal of this study was to investigate the role of excessive copper accumulation in mitochondrial damage and cell apoptosis inhibition. In vivo, the heart copper concentration and cardiac troponin I (c-TnI) and N-terminal forebrain natriuretic peptide (NT-pro-BNP) levels increased in the copper-laden model group compared to those of the control group. Histopathological and ultrastructural observations revealed that the myocardial collagen volume fraction (CVF), perivascular collagen area (PVCA) and cardiomyocyte cross-sectional area (CSA) were markedly elevated in the copper-laden model group compared with the control group. Furthermore, transmission electron microscopy (TEM) showed that the mitochondrial double-layer membrane was incomplete in the copper-laden model groups. Furthermore, cytochrome C (Cyt-C) expression was downregulated in mitochondria but upregulated in the cytoplasm in response to copper accumulation. In addition, Bcl-2 expression decreased, while Bax and cleaved caspase-3 levels increased. These results indicate that copper acc
Who reads Long-term Exposure to Copper Induces Mitochondria-mediated Apoptosis in Mouse Hearts?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Ming Pan; Zi-wei Cheng; Chen-guang Huang; Zhu-qing Ye; Li-jun Sun; Hua Chen; Bei-bei Fu; Kai Zhou; Zhi-rui Fang; Zi-jian Wang; Qing-zhong Xiao; Xue-sheng Liu; Feng-qin Zhu; Shan Gao
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Environmental Science (Physical Sciences)