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Molecular mechanisms of trigeminal neuralgia: A systematic review by Smith, Cynthia A.; Paskhover, Boris; Mammis, Antonios is a Medicine article available to read on EtoBox.

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## Objective: To conduct a systematic review of the available literature for primary research articles identifying potential gene mutations, polymorphisms and other molecular regulatory mechanisms related to trigeminal neuralgia in order to identify the genetic and molecular models of primary trigeminal neuralgia currently being investigated. ## Methods: Pubmed and web of science were systematically searched to identify primary research articles discussing genetic predictors of trigeminal neuralgia and neuropathic pain that were published prior to july 2020. this review was conducted according to prisma guidelines. ## Results: Out of the 333 articles originally identified, a total of 14 papers were selected for study inclusion. these articles included 5 human studies, 6 mouse studies and 3 rat studies. four articles investigated sodium channels, 1 investigated a sodium channel and nerve growth factor receptor, 2 investigated potassium channels, 1 investigated calcium channels, 1 investigated the downstream regulatory element antagonist modulator protein, 1 investigated the dynorphin-kappa opioid receptor system, 1 investigated trpa1, 1 investigated the nrg1/erbb3/erbb2 signaling co

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Author

Smith, Cynthia A.; Paskhover, Boris; Mammis, Antonios

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0303-8467)

Published

2020

Language

EN

Field

Medicine (Health Sciences)