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Can I read Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma on EtoBox?
Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma by Uckun, Fatih M. (author) is a Medicine article available to read on EtoBox.
What is Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma about?
## Simple Summary This article provides a comprehensive review of new and emerging treatment strategies against multiple myeloma that employ precision medicines and/or drugs capable of improving the ability of the immune system to prevent or slow down the progression of multiple myeloma. These rationally designed new treatment methods have the potential to change the therapeutic landscape in multiple myeloma and improve the long-term survival outcome. ## Abstract SeverFigurel cellular elements of the bone marrow (BM) microenvironment in multiple myeloma (MM) patients contribute to the immune evasion, proliferation, and drug resistance of MM cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated M2-like, “alternatively activated” macrophages, CD38+ regulatory B-cells (Bregs), and regulatory T-cells (Tregs). These immunosuppressive elements in bidirectional and multi-directional crosstalk with each other inhibit both memory and cytotoxic effector T-cell populations as well as natural killer (NK) cells. Immunomodulatory imide drugs (IMiDs), protease inhibitors (PI), monoclonal antibodies (MoAb), adoptive T-cell/NK cell therapy, and inhibitors of anti-apoptotic sig
Who reads Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Uckun, Fatih M. (author)
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)