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Can I read Cytocompatible dendrimer G3.0-hematin nanoparticle with high stability and solubility for mimicking horseradish peroxidase activity in in-situ forming hydrogel on EtoBox?
Cytocompatible dendrimer G3.0-hematin nanoparticle with high stability and solubility for mimicking horseradish peroxidase activity in in-situ forming hydrogel by Van Toan Nguyen; Thi Phuong Le; Le Hang Dang; Tan Phuoc Ton; Dinh Trung Nguyen; Nam Nguyen Dang; Bich Tram Nguyen; Vu Van Van; Thi Hiep Nguyen; Ngoc Quyen Tran is a Materials Science article available to read on EtoBox.
What is Cytocompatible dendrimer G3.0-hematin nanoparticle with high stability and solubility for mimicking horseradish peroxidase activity in in-situ forming hydrogel about?
Hematin has been used as an alternative enzyme catalyst to horseradish peroxidase (HRP) due to its iron-containing activity center. Although hematin and it derivatives have been widely used for polymerization of phenol/analine compounds, it has some drawbacks such as the limited solubility and reaction only at high pH condition. Herein, we report a nanosized biomimetic catalyst, hematin-decorated polyamidoamine dendrimer (G3.0-He) that can effectively catalyze the in situ hydrogelation of phenol-conjugated polymers under neutral pH condition. We demonstrate that G3.0-He particles are smaller than 100 nm and have excellent enzyme-mimetic functions. Interestingly, the nanosized catalyst is not inactivated at high HO concentration. Compared to pure hematin, G3.0-He has significantly higher dispersion in acidic and neutral media, and preserves the percentage of survival of fibroblasts over 90%. Notably, G3.0-He possesses an exquisite HRP-mimicking activity in gelation of gelatin derivative with phenolic hydroxyl (tyamine) moieties under mild physiological conditions. The in vitro study demonstrated that Gel-Tyr hydrogel by G3.0-He catalyzed reaction had excellent cytocompatibility and
Who reads Cytocompatible dendrimer G3.0-hematin nanoparticle with high stability and solubility for mimicking horseradish peroxidase activity in in-situ forming hydrogel?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Van Toan Nguyen; Thi Phuong Le; Le Hang Dang; Tan Phuoc Ton; Dinh Trung Nguyen; Nam Nguyen Dang; Bich Tram Nguyen; Vu Van Van; Thi Hiep Nguyen; Ngoc Quyen Tran
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Materials Science (Physical Sciences)