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Potential anti-inflammatory and anti-apoptotic effect of Coccinia grandis plant extract in LPS stimulated-THP-1 cells by Albrahim, Tarfa; Alnasser, Moonerah M.; Al-Anazi, Mashael R.; ALKahtani, Muneera D.; Alkahtani, Saad; Al-Qahtani, Ahmed A. is a Environmental Science article available to read on EtoBox.
What is Potential anti-inflammatory and anti-apoptotic effect of Coccinia grandis plant extract in LPS stimulated-THP-1 cells about?
Coccinia grandis (C. grandis) L is an Indian medicinal plant from the Cucurbitaceae family whose extracts possess anti-oxidant, anti-infective, and anti-inflammatory properties. The objective of the present study was to probe the potential immunomodulatory of C. grandis crude extract on different pathways in THP-1 cells as probed by changes in expression of several proteins. THP-1 cells were differentiated into macrophages after treatment with phorbol-12-myristate 13-acetate, followed by exposure to lipopolysaccharide (LPS) with or without 50 or 100 μg/ml of C. grandis extract. Treatment of the cells with the extract significantly downregulated the expression and release of pro-inflammatory cytokines (IL-6, IL-1β, CCL2, CCL22, CXCL10/IP-10, CX3CL1 and CXCL8/IL-8), proteins (ERK5, BAX, BCL2, Cyclin D, ERK1, NF-κB, P-IκBα,P- NF-κB and P-p38) and molecular signaling pathways (NF-κB, p38 MAPK, ERK1/2 and IL-6/JAK/STAT3 signaling cascades). This study is the first to highlight the ability of C. grandis extract to modulate several pathways, including proliferation, the expression of inflammatory cytokines, phagocytosis, migration properties and apoptosis, in human monocytic THP-1 cells.
Who reads Potential anti-inflammatory and anti-apoptotic effect of Coccinia grandis plant extract in LPS stimulated-THP-1 cells?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Albrahim, Tarfa; Alnasser, Moonerah M.; Al-Anazi, Mashael R.; ALKahtani, Muneera D.; Alkahtani, Saad; Al-Qahtani, Ahmed A.
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Publons; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0944-1344)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Physical Sciences)