Can I read Osteoporosis and major fragility fractures (MOF) in sarcoidosis patients: association with disease severity on EtoBox?

Osteoporosis and major fragility fractures (MOF) in sarcoidosis patients: association with disease severity by Carla Caffarelli; Paolo Cameli; Antonella Al Refaie; Caterina Mondillo; Alessandro Versienti; Giuditta Manasse; Elena Bargagli; Stefano Gonnelli is a Medicine article available to read on EtoBox.

What is Osteoporosis and major fragility fractures (MOF) in sarcoidosis patients: association with disease severity about?

## Abstract ## Background The reports on bone mineral loss or major osteoporosis fracture (MOF) in sarcoidosis are scarce and have conflicting outcomes. This study aimed to evaluate the prevalence and risk factors of MOF in sarcoidosis patients. ## Methods In a single-center cohort of 382 patients with sarcoidosis (55.8 ± 11.6 years) we evaluated bone mineral density at lumbar spine, at femoral neck and at total hip and the presence of MOF. Lung function measurements including diffusion capacity for carbon monoxide (DLCO) were assessed. Chest X-rays were performed and radiological staging was done by Scadding score. ## Results Ninety patients (23.6%) with sarcoidosis have history of a MOF. BMD __T__-scores were lower in sarcoidosis with MOF with respect to those without MOF, but the difference was statistically significant only for BMD at femoral neck (__p__ < 0.05). Moreover, BMD values at total hip was positively correlated with DLCO (%) (__p__ < 0.001). Prevalence of MOF was higher in patients with sarcoidosis with lung parenchymal involvement (radiological stages 2–4) than in patients with sarcoidosis in chest X-ray stages 0 and 1 (28.3 vs 19.2% respectively, __p__ < 0.05). Mor

Who reads Osteoporosis and major fragility fractures (MOF) in sarcoidosis patients: association with disease severity?

Author

Carla Caffarelli; Paolo Cameli; Antonella Al Refaie; Caterina Mondillo; Alessandro Versienti; Giuditta Manasse; Elena Bargagli; Stefano Gonnelli

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)