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Painong-San extract alleviates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota, restoring intestinal barrier function and attenuating TLR4/NF-κB signaling cascades by Kang Wang; Jian Guo; Xiangwei Chang; Shuangying Gui is a Chemistry article available to read on EtoBox.
What is Painong-San extract alleviates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota, restoring intestinal barrier function and attenuating TLR4/NF-κB signaling cascades about?
The intestinal barrier dysfunction and the gut microbiota dysbiosis with excessive progress of inflammation contribute to the occurrence and acceleration of ulcerative colitis (UC). Painong Powder, a traditional Chinese medicine prescription, consists of Aurantii Fructus Immaturus, Paeoniae Radix Alba and Platycodonis Radix, which has been found to defend against colitis, but it is unclear whether its role in preventing UC is related to gut microbiota. This study aims to evaluate the effects of Painong-San extract (PNS) on UC and reveals the mechanisms related to gut microbiota. Firstly, a total of 125 chemical compounds, including 42 flavonoids, 29 triterpenoids, 21 monoterpenoids, 11 polyphenols, 6 limonoids, 5 alkaloids, 4 coumarins and 7 other compounds, were identified from PNS using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. Then, the results in vivo studies demonstrated that PNS treatment reduced the weight loss and the disease activity index, prevented colon shortening and alleviated colonic tissue damage in dextran sulfate sodium (DSS)-induced colitis mice. The intestinal barrier damage was repaired after PNS administration through
Who reads Painong-San extract alleviates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota, restoring intestinal barrier function and attenuating TLR4/NF-κB signaling cascades?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Kang Wang; Jian Guo; Xiangwei Chang; Shuangying Gui
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)
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