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Co-micellization Conduct and Structural Dynamics of Block Copolymers in Water and Salt Solution Environment for Drug Solubilization Enhancement by Divya Patel; Santosh L. Gawali; Ketan Kuperkar; Puthusserickal A. Hassan; Pratap Bahadur is a Chemistry article available to read on EtoBox.

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The present study examines the co-micellization in different block copolymers (BCPs): P123 and F127 (with almost similar hydrophobic PO block but different hydrophilic %EO content). In varying concentration and in presence of NaCl, these BCP solutions in single and mix system displayed a variety of phases, i.e., blue point (BP), thermoreversible gel formation and cloud point (CP) with a noticeable sol-gel phase transition shift. The nanoscale micellar size distribution expressed as hydrodynamic diameter (D h ) was evaluated using dynamic light scattering (DLS). As F127 is larger than P123 and contains more EO groups, the micelle corona appears larger with greater D h . The scattering profile from small-angle x-ray scattering (SAXS) offered information into the micellar dimensions employing SasView 4.2.2 program. The quercetin (QCT) solubilization articulated in encapsulation efficiency (EE%) and drug loading (DL%) followed the enhancement order: P123 > (P123 + F127) > F127 which was inferred from spectral and microscopy study.

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Author

Divya Patel; Santosh L. Gawali; Ketan Kuperkar; Puthusserickal A. Hassan; Pratap Bahadur

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)