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Triglycerides Are Major Determinants of Cholesterol Esterification/Transfer and HDL Remodeling in Human Plasma by Murakami, Toru; Michelagnoli, Silvia; Longhi, Renato; Gianfranceschi, Gemma; Pazzucconi, Franco; Calabresi, Laura; Sirtori, Cesare R.; Franceschini, Guido is a Medicine article available to read on EtoBox.
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__Abstract__ Lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) are responsible for the esterification of cell-derived cholesterol and for the transfer of newly synthesized cholesteryl esters (CE) from HDL to apoB-containing lipoproteins in human plasma. LCAT and CETP are also crucial factors in HDL remodeling, a process by which HDL particles with a high capacity for cell cholesterol uptake are generated in plasma. In the present study, cholesterol esterification and transfer were evaluated in 60 patients with isolated hypercholesterolemia (HC, n=20) and isolated (HTG, n=20) or mixed hypertriglyceridemia (MHTG, n=20) and in 20 normolipidemic healthy individuals (NL). Cholesterol esterification rate (CER) and net CE transfer rate (CETR) were measured in whole plasma. LCAT and CETP concentrations were determined by specific immunoassays. HDL remodeling was analyzed by monitoring changes in HDL particle size distribution during incubation of whole plasma at 37°C. Mean CER and CETR were 48% and 73% higher, respectively, in hypertriglyceridemic (HTG+MHTG) versus normotriglyceridemic individuals. HDL remodeling was also significantly accelerated in
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- Author
- Murakami, Toru; Michelagnoli, Silvia; Longhi, Renato; Gianfranceschi, Gemma; Pazzucconi, Franco; Calabresi, Laura; Sirtori, Cesare R.; Franceschini, Guido
- Publisher
- Lippincott Williams and Wilkins; Ovid Technologies Wolters Kluwer -American Heart Association; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1079-5642)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Health Sciences)