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Can I read Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons on EtoBox?
Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons by Lee, Bora; Kim, Janghyun; An, Taekyeong; Kim, Sangsoo; Patel, Esha M.; Raber, Jacob; Lee, Soo-Kyung; Lee, Seunghee; Lee, Jae W. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons about?
Despite critical roles of the hypothalamic arcuate neurons in controlling the growth and energy homeostasis, the gene regulatory network directing their development remains unclear. Here we report that the transcription factors Dlx1/2 and Otp coordinate the balanced generation of the two functionally related neurons in the hypothalamic arcuate nucleus, GHRH-neurons promoting the growth and AgRP-neurons controlling the feeding and energy expenditure. Dlx1/2-deficient mice show a loss-of-GHRH-neurons and an increase of AgRPneurons, and consistently develop dwarfism and consume less energy. These results indicate that Dlx1/2 are crucial for specifying the GHRH-neuronal identity and, simultaneously, for suppressing AgRP-neuronal fate. We further show that Otp is required for the generation of AgRP-neurons and that Dlx1/2 repress the expression of Otp by directly binding the Otp gene. Together, our study demonstrates that the identity of GHRH-and AgRP-neurons is synchronously specified and segregated by the Dlx1/2-Otp gene regulatory axis.
Who reads Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lee, Bora; Kim, Janghyun; An, Taekyeong; Kim, Sangsoo; Patel, Esha M.; Raber, Jacob; Lee, Soo-Kyung; Lee, Seunghee; Lee, Jae W.
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC; [London]: Nature Publishing Group, 2010-; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 2041-1723)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)