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Tricyclic antidepressants induce apoptosis in human T lymphocytes by Zhenlei Xia; HÅKAN Karlsson; Joseph W. DePierre; Lennart NÄSSBERGER is a Immunology and Microbiology article available to read on EtoBox.

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Apoptosis is a form of programmed cell death that is involved in cell turnover[ In the present study we show that the tricyclic antidepressants "TCAS# imipramine\ clomipramine and citalopram induce apoptosis in human peripheral lymphocytes[ Lymphocytes were incubated with these three drugs for up to 37 h[ Apoptosis was characterized by typical nucleosomal DNA fragmentation on agarose gel\ as well as quantitated using 3?! 5!diamidino!1!phenylindole "DAPI# staining and 2?!OH end!labeling of fragmented DNA at the single cell level[ Apoptosis induced by TCAs was shown to be dose!dependent and could be detected after a 13 h incubation[ The optimal concentrations of the three TCAs found to induce apoptosis were 49 mM imipramine\ 19 mM clomipramine and 079 mM citalopram[ Furthermore\ immuno~uorescence and three!color ~ow cyto! metry were used to identify the phenotype of apoptotic cells[ TCA!induced apoptosis was shown to involve exclusively T!lymphocytes[ Cytotoxic T!lymphocytes were more prone to undergo apoptosis than were T! helper cells[ In conclusion\ the present investigation clearly demonstrates that TCAs exert cell biological e}ects upon human T!lymphocytes[ Further studies are r

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Author

Zhenlei Xia; HÅKAN Karlsson; Joseph W. DePierre; Lennart NÄSSBERGER

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0192-0561)

Published

1998

Language

EN

Field

Immunology and Microbiology (Life Sciences)