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Beta Amyloid Precursor Protein Mediates Neuronal Cell-cell and Cell-surface Adhesion by Dr. K. C. Breen; M. Bruce; B. H. Anderton is a Neuroscience article available to read on EtoBox.

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4, Ireland (K.C.B.) The beta-amyloid precursor protein (APP) is a membrane-bound glycoprotein which has been proposed to play a role both as a growth factor and a mediator of cell adhesion. Using the Neuro-2A neuroblastoma cell line, we have investigated the capacity of APP to mediate neural cell adhesion. The cells express the protein at a high level, the immunohistochemical staining pattern at the level of the membrane having a punctate pattern. Fab' fragments of antibodies to the extracellular portion of the molecule were found to inhibit cell binding to a collagen substrate, but not to laminin, fibronectin, or poly-l-lysine. Fab' fragments of antibodies to the nerve cell adhesion molecule N-CAM also inhibited binding of Neuro-2A cells specifically to collagen. This inhibition of cell-surface binding was accompanied by a repression of neurite outgrowth in differentiating cells in the presence of antibodies. APP antibodies also inhibited neuronneuron and neuron-glial binding, but not glial-glial cell adhesion. These data suggest that the APP, which is expressed primarily on differentiated neuronal cells, may play a role in the mediation of both cell-cell and cell-substrate adhesi

Who reads Beta Amyloid Precursor Protein Mediates Neuronal Cell-cell and Cell-surface Adhesion?

Author

Dr. K. C. Breen; M. Bruce; B. H. Anderton

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1990

Language

EN

Field

Neuroscience (Life Sciences)