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Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism by Sharifia Wills; Christy C Rossi; Jeffrey Bennett; Veronica Martinez Cerdeño; Paul Ashwood; David G Amaral; Judy Van de Water is a Neuroscience article available to read on EtoBox.
What is Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism about?
## Background Autism is a neurodevelopmental disorder characterized by impairments in social interaction and deficits in verbal and nonverbal communication, together with the presence of repetitive behaviors or a limited repertoire of activities and interests. The causes of autism are currently unclear. In a previous study, we determined that 21% of children with autism have plasma autoantibodies that are immunoreactive with a population of neurons in the cerebellum that appear to be Golgi cells, which are GABAergic interneurons. ## Methods We have extended this analysis by examining plasma immunoreactivity in the remainder of the brain. To determine cell specificity, double-labeling studies that included one of the calcium-binding proteins that are commonly colocalized in GABAergic neurons (calbindin, parvalbumin or calretinin) were also carried out to determine which GABAergic neurons are immunoreactive. Coronal sections through the rostrocaudal extent of the macaque monkey brain were reacted with plasma from each of seven individuals with autism who had previously demonstrated positive Golgi cell staining, as well as six negative controls. In addition, brain sections from adult
Who reads Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Sharifia Wills; Christy C Rossi; Jeffrey Bennett; Veronica Martinez Cerdeño; Paul Ashwood; David G Amaral; Judy Van de Water
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2010-; Springer Science and Business Media LLC (ISSN 2040-2392)
- Published
- 2011
- Language
- EN
- Field
- Neuroscience (Life Sciences)