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Can I read Spidroin Silk Fibers with Bioactive Motifs of Extracellular Proteins for Neural Tissue Engineering on EtoBox?
Spidroin Silk Fibers with Bioactive Motifs of Extracellular Proteins for Neural Tissue Engineering by Veronica A. Revkova; Konstantin V. Sidoruk; Vladimir A. Kalsin; Pavel A. Melnikov; Mikhail A. Konoplyannikov; Svetlana Kotova; Anastasia A. Frolova; Sergey A. Rodionov; Mikhail M. Smorchkov; Alexey V. Kovalev; Alexander V. Troitskiy; Peter S. Timashev; Vladimir P. Chekhonin; Vladimir G. Bogush; Vladimir P. Baklaushev is a Engineering article available to read on EtoBox.
What is Spidroin Silk Fibers with Bioactive Motifs of Extracellular Proteins for Neural Tissue Engineering about?
The interaction of neural progenitor cells (NPCs) with the extracellular matrix (ECM) plays an important role in neural tissue regeneration. Understanding which motifs of the ECM proteins are crucial for normal NPC adhesion, proliferation, and differentiation is important in order to create more adequate tissue engineered models of neural tissue and to efficiently study the central nervous system regeneration mechanisms. We have shown earlier that anisotropic matrices prepared from a mixture of recombinant dragline silk proteins, such as spidroin 1 and spidroin 2, by electrospinning are biocompatible with NPCs and provide good proliferation and oriented growth of neurites. This study objective was to find the effects of spidroin-based electrospun materials, modified with peptide motifs of the extracellular matrix proteins (RGD, IKVAV, and VAEIDGIEL) on adhesion, proliferation, and differentiation of directly reprogrammed neural precursor cells (drNPCs). The structural and biomechanical studies have shown that spidroin-based electrospun mats (SBEM), modified with ECM peptides, are characterized by a uniaxial orientation and elastic moduli in the swollen state, comparable to those of
Who reads Spidroin Silk Fibers with Bioactive Motifs of Extracellular Proteins for Neural Tissue Engineering?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Veronica A. Revkova; Konstantin V. Sidoruk; Vladimir A. Kalsin; Pavel A. Melnikov; Mikhail A. Konoplyannikov; Svetlana Kotova; Anastasia A. Frolova; Sergey A. Rodionov; Mikhail M. Smorchkov; Alexey V. Kovalev; Alexander V. Troitskiy; Peter S. Timashev; Vladimir P. Chekhonin; Vladimir G. Bogush; Vladimir P. Baklaushev
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)